Manhunter is a 1986 American thriller film based on Thomas Harris's novel Red Dragon. Written and directed by Michael Mann, it stars William Petersen as Will Graham and features Brian Cox as Hannibal Lecktor. When asked to investigate a killer known as "The Tooth Fairy," FBI profiler Will Graham comes out of retirement to lend his talents to the case—in doing so he must confront the specter of his past and meet with a jailed killer who nearly counted Graham amongst his victims. Dennis Farina co-stars as Jack Crawford, Graham's superior at the FBI, while serial killer Francis Dollarhyde—"The Tooth Fairy"—is portrayed by Tom Noonan.

Manhunter focuses on the forensic work carried out by the FBI to track down the killer, and shows the long-term effects that cases like this have on Graham, highlighting the similarities between him and his quarry. The film features heavily-stylized use of color to convey this sense of duality, and the nature of the characters' similarity has been explored in academic readings of the film. This was not the first adaptation of a Harris novel for the screen—the 1975 novel Black Sunday, a story of a terrorist attack on the Super Bowl, was adapted to film in 1977—but this was the first film to feature the serial killer "Hannibal the Cannibal" who would later appear in The Silence of the Lambs, Hannibal, Red Dragon and Hannibal Rising.

Opening to mixed reviews, Manhunter fared poorly at the box office at the time of its release, making only $8.6 million in the United States on a $15 million budget. However, it has since been reappraised in more recent reviews and now enjoys a more favorable reception, with both the acting and the stylized visuals having gained appreciation in later years. Its resurgent popularity, which may be due to later adaptations of Harris' books and Petersen's success in CSI: Crime Scene Investigation, has seen it labelled as a cult film.