Life Itself is a 2018 American drama film written and directed by Dan Fogelman. It stars Oscar Isaac, Olivia Wilde, Mandy Patinkin, Olivia Cooke, Laia Costa, Annette Bening, and Antonio Banderas, and follows multiple couples over numerous generations, and how they are all connected by a single event.The film had its world premiere at the Toronto International Film Festival on September 8, 2018, and was released in the United States on September 21, 2018, by Amazon Studios.